December 8, 2022

Vybirai Ka

Specialists In Health

Collaborating to Advance Biomarker Testing

Collaborating to Advance Biomarker Testing

Collaborating to Advance Biomarker Testing
Credit score: AstraZeneca

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Omar Perez, PhD, RAC
Omar Perez, PhD, RAC

Omar Perez, PhD, RAC, Head of Medical Diagnostics, U.S. Medical Affairs, Oncology at AstraZeneca, lately shared with Inside Precision Medication (IPM) the significance of taking a collaborative and complete strategy to precision drugs to make sure a greater affected person expertise.

IPM:  Who’s concerned within the affected person’s expertise with precision drugs? What is required to unite the assorted stakeholders concerned?

A number of key people are sometimes concerned in a affected person’s precision drugs journey, from household or caregivers to the medical workforce and specialists chargeable for overseeing the individual’s remedy. Past the affected person’s care workforce, researchers and pharmaceutical firms directing scientific trials to develop revolutionary new therapies, in addition to policymakers overseeing remedy availability, are additionally deeply embedded. By way of collaboration, this community has the potential to ease an individual’s remedy pathway and alleviate among the main limitations to care. In the end, the danger of poor affected person outcomes grows with out a frequent language round precision drugs and misaligned remedy approaches.

Nevertheless, at AstraZeneca, we imagine that via a collaborative effort to codify precision drugs terminology, standardize diagnostic and remedy practices, and streamline communication, we have now the potential to make biomarker take a look at­ing extra accessible—and in the end, assist guarantee all sufferers can obtain well timed and correct details about the genetic mutations inflicting their particular most cancers no matter their tumor kind, illness stage, or the place they’re receiving care.

AstraZeneca is in search of methods to deliver the neighborhood collectively to handle these limitations, and a few of this collaborative work is already underway. Earlier this yr, we hosted a roundtable fea­turing key teams throughout the area to assemble their distinctive insights and views. We have now additionally supported the Affiliation of Group Most cancers Facilities’ nationwide multi-phase initiative—Fostering Excellence in Care and Outcomes in Sufferers with Stage III and IV non-small cell lung most cancers (NSCLC)—which leverages multidisciplinary care groups to know present limitations higher and create and execute course of enchancment plans to help the optimization of look after sufferers identified with phases III and IV NSCLC. Moreover, we have now joined Entry to Complete Genomic Profiling, a coalition of business specialists devoted to advancing complete genomic profiling for superior most cancers sufferers.

IPM:  What makes navigating the panorama of biomarker testing and precision drugs so complicated for researchers, pharmaceutical firms, healthcare suppliers (HCPs), policymakers and, most significantly, sufferers?

The highway from most cancers detection to remedy initiation is lengthy, complicated, and stuffed with limitations which will hinder the optimum use of biomarker testing amongst all sufferers. For instance:

• The outputs of biomarker testing will be difficult to know and talk, and a few physicians discover the interpretation course of cumbersome and time-consuming.

• Testing terminology is inconsistent and complicated, hampering affected person and HCPs’ understanding of precision drugs.

• The shortage of standardized testing processes is additional compli­cated by a continuing stream of latest illness/biomarker/assay-specific tips.

• Medical trials are inaccessible to the broader inhabitants, limiting affected person entry to biomarker testing and reducing its scientific utility.

Addressing these limitations requires a collaborative strategy, and at AstraZeneca, we all know we’re only one piece of the puzzle. We’d like the collective experience of your entire oncology neighborhood to attain significant change for these affected by and residing with most cancers.

IPM:  How can collaboration speed up advances in biomarker testing whereas additionally simplifying the panorama and enhancing entry to biomarker testing for these impacted by most cancers?

We imagine multidisciplinary collaboration is vital to fixing complicated points inside precision drugs. This includes harnessing the collective experience of your entire oncology neighborhood—from affected person advocates and HCPs to coverage specialists and payers—to make sure well being coverage and finest practices work synergistically.

In the end, a collaborative strategy has the potential to determine biomarker testing as a vital part of high-quality most cancers look after all sufferers and rework the usual of oncology care into one that’s constant but tailor-made to sufferers’ distinct wants.

IPM:  In what areas have we seen collaborative success in addressing particular points inside precision drugs? Are you able to share examples of initiatives which have demonstrated tangible affect?

We have now engaged in a number of partnerships to lift consciousness round biomarker testing and focused therapies via training, advocated for precision drugs approaches to oncology by eradicating limitations to entry and advancing coverage, and sought to realize a deeper understanding of limitations to precision drugs via additional analysis and insights from stakeholders.

From an training standpoint, AstraZeneca helps a number of efforts to assist sufferers, HCPs, and policymakers broaden their understanding of biomarker testing and precision drugs. This work contains initiatives similar to:

• It’s OK to Ask, which was designed to handle the stigma round lung most cancers and empower these impacted by it within the Asian American neighborhood to take a extra proactive strategy to remedy.

• The No One Missed marketing campaign, which goals to empower sufferers and caregivers to request complete biomarker testing from their healthcare workforce on the time of prognosis, recurrence, or development. Particular to lung most cancers, we have now partnered with PGA champion, Jason Day and his mom to type the Full Your Analysis marketing campaign, which focuses on the significance of biomarker testing in stage IV NSCLC primarily based on their household’s expertise navigating the illness.

Our collaborative entry and coverage work seeks to make sure all sufferers have correct and well timed details about their particular kind of most cancers. For instance:

• Our work with the YOUR Most cancers program brings collectively sufferers, caregivers, advocacy teams, researchers, HCPs, and policymakers to rework most cancers care by driving change in precision drugs and enhancing early intervention, entry, and well being fairness.

• We’re additionally a founding member of the Lung Ambition Alliance, via which we work with business and nonprofit companions to extend early prognosis and make sure the implementation of screening packages and elevated biomarker testing.

Directing the way forward for biomarker testing and precision drugs requires a complete understanding of the present panorama. That’s why AstraZeneca, in collaboration with Personalised Medi­cine Coalition and Well being Advances LLC, sought the viewpoints of surgeons, oncologists, lab administrators, payers, and sufferers to know perceived limitations to precision drugs higher and in the end uncover methods to assist bolster its wider adoption throughout america. The findings, revealed within the Journal of Personalised Medication, revealed a disconnect between clinicians and sufferers on the relative degree of consciousness of biomarker testing and entry. These findings underscore the significance of our work to handle limitations to testing alongside our neighborhood companions and fortify our ambition to enhance most cancers survival.

IPM:  How does AstraZeneca strategy strategic partnerships?

At AstraZeneca, we search to function a convener and enabler of these within the most cancers neighborhood who’re serving to obtain daring objectives in most cancers. We all know pharmaceutical analysis and improvement advances rapidly, and we see an necessary alternative for us to help the broader oncology neighborhood by translating science into drugs. This includes synthesizing scientific data and translating findings about remedies or diagnostics right into a language that may be higher understood by the broader healthcare neighborhood, together with individuals who could also be navigating a most cancers prognosis. We glance to our companions with experience throughout disciplines to interact in significant conversations and devise complementary approaches to precedence points for folks impacted by most cancers.


Dr. Omar Perez has almost 20 years of expertise designing, deploying, and main high-visibility oncology initiatives supporting world companion diagnostic developments, strategic partnerships, and commercialization alternatives. Earlier than becoming a member of AstraZeneca, he oversaw the worldwide companion diagnostic (CDx) developments for GlaxoSmithKline’s oncology portfolio and led world CDx actions supporting quite a few drug approvals for Pfizer. Notably, he led the primary FDA-approved next-generation sequencing product for a number of focused brokers and helped set up the Middle for Precision Medication in Latin America to help Pfizer oncology merchandise. Dr. Perez’s background contains roles in biotech and diagnostic firms, together with co-founding Nodality, a diagnostic firm targeted on hematological malignancies. He’s an inventor of the multiparametric phospho-proteomic stream applied sciences and an creator of 37 publications and 35 patents.


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