Editas Medication Pronounces Third Quarter 2022 Outcomes and

Dosed second affected person with EDIT-301 within the Part 1/2 RUBY trial for sickle cell illness

On monitor to announce preliminary preliminary scientific knowledge from RUBY trial by year-end

Accomplished cell modifying and presently scheduling first affected person dosing with EDIT-301 in Part 1/2 EDITHAL trial for TDT

Firm to offer a scientific replace on the Part 1/2 BRILLIANCE trial for EDIT-101 this month

CAMBRIDGE, Mass., Nov. 02, 2022 (GLOBE NEWSWIRE) — Editas Medication, Inc. (Nasdaq: EDIT), a scientific stage genome modifying firm, immediately reported enterprise highlights and monetary outcomes for the third quarter of 2022.

“I’m happy with our continued progress, and I stay up for offering scientific updates on EDIT-101 and EDIT-301 within the subsequent two months,” commented Gilmore O’Neill, M.B., M.M.Sc., President and Chief Govt Officer, Editas Medication. “We’re centered on positioning and advancing our portfolio in direction of our objective of bringing differentiated medicines to folks dwelling with critical illnesses.”

Current Achievements and Outlook

Ex Vivo Medicines

• EDIT-301 for Sickle Cell Illness
  Second affected person dosed in RUBY trial; on monitor to offer preliminary scientific knowledge by year-end
  • Editas Medication has dosed the second affected person and continues to enroll examine contributors within the Part 1/2 RUBY trial for the remedy of extreme sickle cell illness.
  • The Firm stays on monitor to current preliminary preliminary scientific knowledge for the RUBY examine by year-end.
• EDIT-301 for Transfusion-Dependent Beta Thalassemia (TDT)
  First affected person apheresis and modifying accomplished
  • The Firm has accomplished modifying CD34+ hematopoietic stem cells for the primary enrolled affected person within the Part 1/2 EDITHAL trial for TDT and is scheduling dosing.

In Vivo Medicines 

• EDIT-101 for Leber Congenital Amaurosis 10 (LCA10)
  BRILLIANCE scientific replace to be supplied this month
  • The Firm stays on monitor to offer an replace on the Part 1/2 BRILLIANCE scientific trial this month, together with security and efficacy knowledge.

• EDIT-103 for Rhodopsin-Related Autosomal Dominant Retinitis Pigmentosa (RHO-adRP)
  Offered preclinical knowledge at ESGCT
  • In October, Editas Medication offered preclinical knowledge throughout an oral presentation on the European Society of Gene and Cell Remedy (ESGCT) Annual Assembly.
  • The info demonstrated practically 100% gene modifying knockout of the endogenous RHO gene, with the substitute RHO gene producing over 30% of regular RHO protein ranges within the handled space of subretinal injection in non-human primates handled with EDIT-103.

Mobile Therapies

• EDIT-202 Multiplexed iNK for Stable Tumors
  Offered new preclinical knowledge at ESGCT
  • In October, the Firm offered new preclinical knowledge in a poster presentation on the ESGCT Annual Assembly. EDIT-202 is an engineered iNK cell product, presently in preclinical growth, that mixes Editas Medication’s proprietary AsCas12a enzyme and SLEEK™ gene modifying know-how, and seeks to handle the unmet want for treating strong tumors.
  • The info demonstrated extended persistence, excessive cytotoxicity, and enhanced in vivo management of strong tumors.

Third Quarter 2022 Monetary Outcomes

• Money, money equivalents, and marketable securities as of September 30, 2022, have been $478.5 million, in comparison with $527.6 million as of June 30, 2022. The Firm expects that its current money, money equivalents and marketable securities will allow it to fund its working bills and capital expenditures into 2024.
• For the three months ended September 30, 2022, internet loss attributable to widespread stockholders was $55.7 million, or $0.81 per share, in comparison with internet lack of $39.1 million, or $0.57 per share, for a similar interval in 2021.
• Collaboration and different analysis and growth revenues have been $42 thousand for the three months ended September 30, 2022, in comparison with $6.2 million for a similar interval in 2021. The 2021 interval included income acknowledged for an opt-in by Bristol Myers Squibb (BMS) beneath the Firm’s collaboration with BMS; there was no corresponding income within the third quarter of 2022.
• Analysis and growth bills have been $41.3 million for the three months ended September 30, 2022, in comparison with $29.3 million for a similar interval in 2021. The rise was primarily pushed by elevated manufacturing bills, in addition to scientific trial prices.
• Basic and administrative bills have been flat at $16.2 million for the three months ended September 30, 2022, in comparison with the identical interval in 2021.

Editas Medication plans to take part within the following scientific and medical conferences:

• Society for Immunotherapy of Most cancers (SITC) 37^th Annual Assembly
  November 8-12, 2022 – Boston, MA

• American Society for Hematology (ASH) 64^th Annual Assembly
  December 10-13, 2022 – New Orleans, LA

Editas Medication plans to take part within the following investor occasions:

• 5^th Annual Evercore ISI HealthCONx Convention
  November 29, 2022 – Digital

Convention Name
The Editas Medication administration crew will host a convention name and webcast immediately at 8:00 a.m. ET to offer and focus on a company replace and monetary outcomes for the third quarter of 2022. To entry the decision, please dial 877-407-0989 (home) or 201-389-0921 (worldwide) and ask for the Editas Medication earnings name. A stay webcast of the decision will even be out there on the Buyers part of the Editas Medication web site at www.editasmedicine.com, and a replay shall be out there roughly two hours after its completion.

About Editas Medication
As a scientific stage genome modifying firm, Editas Medication is targeted on translating the ability and potential of the CRISPR/Cas9 and CRISPR/Cas12a genome modifying techniques into a strong pipeline of remedies for folks dwelling with critical illnesses all over the world. Editas Medication goals to find, develop, manufacture, and commercialize transformative, sturdy, precision genomic medicines for a broad class of illnesses. Editas Medication is the unique licensee of Broad Institute’s and Harvard College’s Cas9 patent estates and Broad Institute’s Cas12a patent property for human medicines. For the most recent data and scientific shows, please go to www.editasmedicine.com.

Ahead-Trying Statements
This press launch comprises forward-looking statements and data inside the which means of The Personal Securities Litigation Reform Act of 1995. The phrases ‘‘anticipate,’’ ‘‘imagine,’’ ‘‘proceed,’’ ‘‘might,’’ ‘‘estimate,’’ ‘‘anticipate,’’ ‘‘intend,’’ ‘‘could,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘mission,’’ ‘‘goal,’’ ‘‘ought to,’’ ‘‘would,’’ and comparable expressions are meant to establish forward-looking statements, though not all forward-looking statements include these figuring out phrases. Ahead-looking statements on this press launch embody statements relating to the initiation, timing, progress and outcomes of the Firm’s preclinical and scientific research and its analysis and growth packages, the timing for the Firm’s receipt and presentation of information from its scientific trials and preclinical research, together with preliminary preliminary scientific knowledge from the RUBY trial by year-end 2022 and a scientific replace on the BRILLIANCE trial in November 2022, potential of, and expectations for, the Firm’s product candidates, the timing or probability of regulatory filings and approvals, and the Firm’s expectations relating to money runway. The Firm could not truly obtain the plans, intentions, or expectations disclosed in these forward-looking statements, and you shouldn’t place undue reliance on these forward-looking statements. Precise outcomes or occasions might differ materially from the plans, intentions and expectations disclosed in these forward-looking statements because of varied essential elements, together with: uncertainties inherent within the initiation and completion of pre-clinical research and scientific trials, together with the BRILLIANCE, RUBY and EDITHAL trials, and scientific growth of the Firm’s product candidates; availability and timing of outcomes from pre-clinical research and scientific trials; whether or not interim outcomes from a scientific trial shall be predictive of the ultimate outcomes of the trial or the outcomes of future trials; expectations for regulatory approvals to conduct trials or to market merchandise and availability of funding adequate for the Firm’s foreseeable and unforeseeable working bills and capital expenditure necessities. These and different dangers are described in better element beneath the caption “Threat Components” included within the Firm’s most up-to-date Annual Report on Kind 10-Ok, which is on file with the Securities and Trade Fee, as up to date by the Firm’s subsequent filings with the Securities and Trade Fee, and in different filings that the Firm could make with the Securities and Trade Fee sooner or later. Any forward-looking statements contained on this press launch symbolize Firm’s views solely as of the date hereof and shouldn’t be relied upon as representing its views as of any subsequent date. Besides as required by regulation, the Firm explicitly disclaims any obligation to replace any forward-looking statements.

EDITAS MEDICINE, INC.
Consolidated Assertion of Operations
(quantities in hundreds, besides share and per share knowledge)
(Unaudited)

	Three Months Ended							9 Months Ended
	September 30,							September 30,
		2022			2021			2022			2021
Collaboration and different analysis
and growth revenues	$	42		$	6,197		$	13,176		$	13,075
Working bills:
Analysis and growth		41,326			29,265			122,960			104,954
Basic and administrative		16,236			16,185			52,720			59,657
Whole working bills		57,562			45,450			175,680			164,611
Working loss		(57,520)			(39,253)			(162,504)			(151,536)
Different revenue, internet:
Different revenue, internet		1			19			4			38
Curiosity revenue, internet		1,793			152			2,806			432
Whole different revenue, internet		1,794			171			2,810			470
Web loss	$	(55,726)		$	(39,082)		$	(159,694)		$	(151,066)
Web loss per share attributable
to widespread stockholders,
primary and diluted	$	(0.81)		$	(0.57)		$	(2.33)		$	(2.24)
Weighted-average widespread
shares excellent, primary and
diluted		68,736,125			68,219,742			68,621,574			67,371,246

EDITAS MEDICINE, INC.
Chosen Consolidated Stability Sheet Objects
(quantities in hundreds)
(Unaudited)

	September 30,			December 31,
	2022			2021
Money, money equivalents, and marketable securities	$	478,461		$	619,916
Working capital		384,340			460,426
Whole belongings		531,029			677,483
Deferred income, internet of present portion		64,667			60,888
Whole stockholders’ fairness		414,745			553,642

Media Contact:
Cristi Barnett
(617) 401-0113
[email protected]

Investor Contact:
Ron Moldaver
(617) 401-9052
[email protected]